Sylvion

You start out Sylvion by creating your deck according to a specific set of rules as well as some random chance. You then set up the board of cards (which does take up alot of real estate) and try to defeat the game by playing cards, discarding other cards to pay their cost, that do a variety of things. This feels kinda like a solo game of MTG. Very puzzly, very fun. The two player coop variant plays almost the same except that your partner pays for cards you wish to use and vice versa. This makes the game dynamics surprisingly different. I love it since the first part (the deck building) will dictate the strategy for the second part, much in the same way as MTG. There are many different ways to win in this game which requires a change in mindset and playstyle, again much like MTG. On top of that the game comes with a few mini expansions that enhance the game further.

Tower defense game with card drafting. Can be brutally difficult to win until you discover the right strategies (though it's still no guarantee). Included expansions add variability. 2 player is more difficult than solo but make sure you check BGG for the errata as English translation of rulebook uses a more difficult variant for 2 player than what was in the original rules (and which the designer confirmed as correct).